| Official Name |
|---|
| Methylenetetrahydrofolate reductase (NAD(P)H).
|
| Alternative Name(s) |
|---|
| 5,10-CH(2)-H(4)folate reductase. |
| 5,10-methylenetetrahydrofolate reductase. |
| 5,10-methylenetetrahydrofolate reductase (FADH(2)). |
| 5,10-methylenetetrahydrofolate reductase (NADPH). |
| 5,10-methylenetetrahydrofolic acid reductase. |
| 5,10-methylenetetrahydropteroylglutamate reductase. |
| 5-methyltetrahydrofolate:(acceptor) oxidoreductase. |
| 5-methyltetrahydrofolate:NAD oxidoreductase. |
| 5-methyltetrahydrofolate:NAD(+) oxidoreductase. |
| 5-methyltetrahydrofolate:NADP(+) oxidoreductase. |
| Methylenetetrahydrofolate (reduced nicotinamide adenine dinucleotide
phosphate) reductase. |
| Methylenetetrahydrofolate (reduced riboflavin adenine dinucleotide)
reductase. |
| Methylenetetrahydrofolate reductase. |
| Methylenetetrahydrofolate reductase (NADPH(2)). |
| Methylenetetrahydrofolate reductase (NADPH). |
| Methylenetetrahydrofolic acid reductase. |
| MTHFR. |
| N(5),N(10)-methylenetetrahydrofolate reductase. |
| N(5,10)-methylenetetrahydrofolate reductase. |
| Reaction catalysed |
|---|
| 5-methyltetrahydrofolate + NAD(P)(+) <=> 5,10-methylenetetrahydrofolate + NAD(P)H |
| Cofactor(s) |
|---|
| FAD.
|
| Comment(s) |
|---|
- Menadione can also serve as an electron acceptor.
- Formerly EC 1.1.1.68, EC 1.1.1.171 and EC 1.1.99.15.
|
| Cross-references |
|---|
| Biochemical Pathways; map number(s) | B7 |
| BRENDA | 1.5.1.20 |
| PUMA2 | 1.5.1.20 |
| PRIAM enzyme-specific profiles | 1.5.1.20 |
| KEGG Ligand Database for Enzyme Nomenclature | 1.5.1.20 |
| IUBMB Enzyme Nomenclature | 1.5.1.20 |
| IntEnz | 1.5.1.20 |
| MEDLINE | Find literature relating to 1.5.1.20 |
| MetaCyc | 1.5.1.20 |
| UniProtKB/Swiss-Prot |
| O67422, METF_AQUAE; | P57154, METF_BUCAI; | Q8KA62, METF_BUCAP; |
| Q89B13, METF_BUCBP; | P0AEZ1, METF_ECOLI; | P45208, METF_HAEIN; |
| Q9JZQ3, METF_NEIMB; | P71319, METF_PECCC; | P11003, METF_SALTY; |
| P0AEZ2, METF_SHIFL; | O54235, METF_STRLI; | Q9SE60, MTHR1_ARATH; |
| Q9SE94, MTHR1_MAIZE; | Q10258, MTHR1_SCHPO; | P46151, MTHR1_YEAST; |
| O80585, MTHR2_ARATH; | O74927, MTHR2_SCHPO; | P53128, MTHR2_YEAST; |
| Q5I598, MTHR_BOVIN; | Q17693, MTHR_CAEEL; | P42898, MTHR_HUMAN; |
| Q60HE5, MTHR_MACFA; | Q9WU20, MTHR_MOUSE; | Q75HE6, MTHR_ORYSJ; |
|
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