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NiceZyme View of ENZYME: EC 1.5.1.12

Accepted Name
1-pyrroline-5-carboxylate dehydrogenase.
Reaction catalysed
(S)-1-pyrroline-5-carboxylate + NAD(P)(+) + 2 H(2)O <=> L-glutamate + NAD(P)H
Comment(s)
  • Oxidizes a number of 1-pyrrolines, e.g. 3-hydroxy-1-pyrroline-5- carboxylate is converted into 4-hydroxyglutamate and (R)-1-pyrroline- 5-carboxylate is converted into D-glutamate.
  • While NAD(+) appears to be the better electron acceptor, NADP(+) can also act, but more slowly.
  • In many organisms, ranging from bacteria to mammals, proline is oxidized to glutamate in a two-step process involving this enzyme and EC 1.5.99.8.
  • In many bacterial species, both activities are carried out by a single bifunctional enzyme.
Cross-references
Biochemical Pathways; map number(s)H7 ; I7
PROSITEPDOC00068
BRENDA1.5.1.12
EC2PDB1.5.1.12
PRIAM enzyme-specific profiles1.5.1.12
KEGG Ligand Database for Enzyme Nomenclature1.5.1.12
IUBMB Enzyme Nomenclature1.5.1.12
IntEnz1.5.1.12
MEDLINEFind literature relating to 1.5.1.12
MetaCyc1.5.1.12
UniProtKB/Swiss-Prot
Q8VZC3, AL121_ARATH;  A7YWE4, AL4A1_BOVIN;  Q7SY23, AL4A1_DANRE;  
Q54RA2, AL4A1_DICDI;  P30038, AL4A1_HUMAN;  Q8CHT0, AL4A1_MOUSE;  
P0C2X9, AL4A1_RAT;  P78568, PUT2_AGABI;  Q9P8I0, PUT2_EMENI;  
O74766, PUT2_SCHPO;  P07275, PUT2_YEAST;  P09546, PUTA_ECOLI;  
O52485, PUTA_KLEAE;  P23725, PUTA_KLEPN;  P95629, PUTA_RHIME;  
P10503, PUTA_SALTY;  Q9K9B2, ROCA1_BACHD;  Q9K5Z5, ROCA2_BACHD;  
P94391, ROCA2_BACSU;  B7GFV3, ROCA_ANOFW;  A0R909, ROCA_BACAH;  
Q81ZF8, ROCA_BACAN;  B7JM99, ROCA_BACC0;  P62028, ROCA_BACC1;  
B7IUW8, ROCA_BACC2;  B7H4V1, ROCA_BACC4;  B7HSW8, ROCA_BACC7;  
A7GKJ4, ROCA_BACCN;  Q81IP0, ROCA_BACCR;  Q63GS0, ROCA_BACCZ;  
Q6HP91, ROCA_BACHK;  Q65NN2, ROCA_BACLD;  A8F9T1, ROCA_BACP2;  
P39634, ROCA_BACSU;  A9VRG6, ROCA_BACWK;  Q5L3K8, ROCA_GEOKA;  
A4IJP9, ROCA_GEOTN;  Q8ERF4, ROCA_OCEIH;  A7X6R7, ROCA_STAA1;  
A6U4T5, ROCA_STAA2;  Q2FDV3, ROCA_STAA3;  Q2FV67, ROCA_STAA8;  
A5IVY0, ROCA_STAA9;  Q2YWA6, ROCA_STAAB;  Q5HCZ6, ROCA_STAAC;  
A6QK44, ROCA_STAAE;  P63939, ROCA_STAAM;  P99076, ROCA_STAAN;  
Q6GDP4, ROCA_STAAR;  Q6G6C0, ROCA_STAAS;  A8Z3F5, ROCA_STAAT;  
Q8NUR2, ROCA_STAAW;  Q5HL59, ROCA_STAEQ;  Q8CN04, ROCA_STAES;  
Q4L966, ROCA_STAHJ;  Q4A0E7, ROCA_STAS1;  

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All UniProtKB/Swiss-Prot entries referenced in this entry, with possibility to download in different formats, align etc.
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 1.5.1.-
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 1.5.-.-
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 1.-.-.-

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