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ENZYME

ENZYME entry: EC 1.21.3.7

Accepted Name
tetrahydrocannabinolic acid synthase
Alternative Name(s)
Delta(1)-tetrahydrocannabinolic acid synthase
THCA synthase
Reaction catalysed
cannabigerolate + O2 <=> Delta(9)-tetrahydrocannabinolate + H2O2
Comment(s)
  • The cofactor is covalently bound.
  • Part of the cannabinoids biosynthetic pathway in the plant Cannabis sativa.
  • The enzyme can also convert cannabinerolate (the (Z)-isomer of cannabigerolate) to Delta(9)-THCA with lower efficiency.
  • The traditional numbering called Delta(9)-tetrahydrocannabinolate, Delta(1)-tetrahydrocannabinolate.
  • Systematic peripheral numbering is now recommended.
Cross-references
BRENDA1.21.3.7
EC2PDB1.21.3.7
ExplorEnz1.21.3.7
PRIAM enzyme-specific profiles1.21.3.7
KEGG Ligand Database for Enzyme Nomenclature1.21.3.7
IUBMB Enzyme Nomenclature1.21.3.7
IntEnz1.21.3.7
MEDLINEFind literature relating to 1.21.3.7
MetaCyc1.21.3.7
Rhea expert-curated reactions1.21.3.7
UniProtKB/Swiss-Prot
Q8GTB6, THCAS_CANSA

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