| Accepted Name |
|---|
| acyl-lipid (11-3)-desaturase
|
| Alternative Name(s) |
|---|
| acyl-lipid 8-desaturase |
| Delta(8)-desaturase |
| SLD |
| Reaction catalysed |
|---|
- an (11Z,14Z)-icosadienoyl-containing glycerolipid + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2 <=> an (8Z,11Z,14Z)-icosatrienoyl-containing glycerolipid + 2 Fe(III)-[cytochrome b5] + 2 H2O
- an (11Z,14Z,17Z)-icosatrienoyl-containing glycerolipid + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2 <=> an (8Z,11Z,14Z,17Z)-eicosatetraenoyl-containing glycerolipid + 2 Fe(III)-[cytochrome b5] + 2 H2O
|
| Comment(s) |
|---|
- The enzyme, characterized from the protist Euglena gracilis and the
microalga Rebecca salina, introduces a cis double bond at the
8-position in 20-carbon fatty acids that are incorporated into a
glycerolipid and have an existing Delta(11) desaturation.
- The enzyme is a front-end desaturase, introducing the new double bond
between the pre-existing double bond and the carboxyl-end of the
fatty acid.
- It contains a cytochrome b5 domain that acts as the direct electron
donor to the active site of the desaturase, and does not require an
external cytochrome.
- Involved in alternative pathways for the biosynthesis of the
polyunsaturated fatty acids arachidonate and icosapentaenoate.
- Formerly EC 1.14.19.n1.
|
| Cross-references |
|---|
| BRENDA | 1.14.19.4 |
| EC2PDB | 1.14.19.4 |
| ExplorEnz | 1.14.19.4 |
| PRIAM enzyme-specific profiles | 1.14.19.4 |
| KEGG Ligand Database for Enzyme Nomenclature | 1.14.19.4 |
| IUBMB Enzyme Nomenclature | 1.14.19.4 |
| IntEnz | 1.14.19.4 |
| MEDLINE | Find literature relating to 1.14.19.4 |
| MetaCyc | 1.14.19.4 |
| Rhea expert-curated reactions | 1.14.19.4 |
| UniProtKB/Swiss-Prot |
|
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All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 1.14.-.-
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