ID   1.14.17.3
DE   Peptidylglycine monooxygenase.
AN   PAM.
AN   Peptidyl alpha-amidating enzyme.
AN   Peptidylglycine 2-hydroxylase.
AN   Peptidylglycine alpha-amidating monooxygenase.
CA   Peptidylglycine + ascorbate + O(2) = peptidyl(2-hydroxyglycine) +
CA   dehydroascorbate + H(2)O.
CF   Copper.
CC   -!- Peptidylglycines with a neutral amino acid residue in the penultimate
CC       position are the best substrates for the enzyme.
CC   -!- The product is unstable and dismutates to glyoxylate and the
CC       corresponding desglycine peptide amide, a reaction catalyzed by
CC       EC 4.3.2.5.
CC   -!- Involved in the final step of biosynthesis of alpha-melanotropin and
CC       related biologically active peptides.
PR   PROSITE; PDOC00080;
DR   P08478, AMD1_XENLA ;  P12890, AMD2_XENLA ;  P83388, AMDL_CAEEL ;
DR   P10731, AMD_BOVIN  ;  P19021, AMD_HUMAN  ;  P97467, AMD_MOUSE  ;
DR   P14925, AMD_RAT    ;  Q95XM2, PHM_CAEEL  ;  O01404, PHM_DROME  ;
//