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NiceZyme View of ENZYME: EC 1.14.13.70

Accepted Name
Sterol 14-demethylase.
Alternative Name(s)
Cytochrome P450 51.
Lanosterol 14-alpha-demethylase.
Lanosterol 14-demethylase.
Obtusufoliol 14-demethylase.
Sterol 14-alpha-demethylase.
Reaction catalysed
Obtusifoliol + 3 O(2) + 3 NADPH <=> 4-alpha-methyl-5-alpha-ergosta-8,14,24(28)-trien-3-beta-ol + formate + 3 NADP(+) + 4 H(2)O
Cofactor(s)
Heme-thiolate.
Comment(s)
  • The enzyme (P450) catalyzes successive hydroxylations of the 14-alpha-methyl group and C-15, followed by elimination as formate leaving the 14(15) double bond.
  • This enzyme acts on a range of steroids with a 14-alpha-methyl group.
Cross-references
PROSITEPDOC00081
BRENDA1.14.13.70
EC2PDB1.14.13.70
PRIAM enzyme-specific profiles1.14.13.70
KEGG Ligand Database for Enzyme Nomenclature1.14.13.70
IUBMB Enzyme Nomenclature1.14.13.70
IntEnz1.14.13.70
MEDLINEFind literature relating to 1.14.13.70
MetaCyc1.14.13.70
UniProtKB/Swiss-Prot
Q4PJW3, CP51A_BOVIN;  Q16850, CP51A_HUMAN;  Q4R8S6, CP51A_MACFA;  
Q8K0C4, CP51A_MOUSE;  O46420, CP51A_PIG;  Q5RE72, CP51A_PONAB;  
Q64654, CP51A_RAT;  Q759W0, CP51_ASHGO;  P10613, CP51_CANAL;  
P50859, CP51_CANGA;  P14263, CP51_CANTR;  Q9UVC3, CP51_CUNEL;  
Q1ZXH9, CP51_DICDI;  Q02315, CP51_ISSOR;  Q5UQI3, CP51_MIMIV;  
P0A513, CP51_MYCBO;  P0A512, CP51_MYCTU;  Q5IZM4, CP51_MYCVP;  
Q12664, CP51_PENIT;  Q09736, CP51_SCHPO;  P93846, CP51_SORBI;  
Q7Z1V1, CP51_TRYCR;  O14442, CP51_UNCNE;  P49602, CP51_USTMA;  
P93596, CP51_WHEAT;  P10614, CP51_YEAST;  

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