| Official Name |
|---|
| Pentachlorophenol monooxygenase.
|
| Alternative Name(s) |
|---|
| PCB 4-monooxygenase. |
| PCB4MO. |
| PCP hydroxylase. |
| Pentachlorophenol 4-monooxygenase. |
| Pentachlorophenol dechlorinase. |
| Pentachlorophenol dehalogenase. |
| Pentachlorophenol hydroxylase. |
| Reaction catalysed |
|---|
- Pentachlorophenol + 2 NADPH + O(2) <=> 2,3,5,6-tetrachlorohydroquinone + 2 NADP(+) + chloride + H(2)O
- 2,3,5,6-tetrachlorophenol + NADPH + O(2) <=> 2,3,5,6-tetrachlorohydroquinone + NADP(+) + H(2)O
|
| Cofactor(s) |
|---|
| FAD.
|
| Comment(s) |
|---|
- The enzyme displaces a diverse range of substituents from the
4-position of polyhalogenated phenols but requires that a halogen
substituent be present at the 2-position.
- The enzyme converts many polyhalogenated phenols into hydroquinones,
and requires that a halogen substituent be present at C-2.
- If C-4 carries a halogen substituent, reaction 1 is catalyzed, e.g.
2,4,6-triiodophenol is oxidized to 2,6-diiodohydroquinone; if C-4 is
unsubstituted, reaction 2 is catalyzed.
|
| Cross-references |
|---|
| BRENDA | 1.14.13.50 |
| PUMA2 | 1.14.13.50 |
| PRIAM enzyme-specific profiles | 1.14.13.50 |
| KEGG Ligand Database for Enzyme Nomenclature | 1.14.13.50 |
| IUBMB Enzyme Nomenclature | 1.14.13.50 |
| IntEnz | 1.14.13.50 |
| MEDLINE | Find literature relating to 1.14.13.50 |
| MetaCyc | 1.14.13.50 |
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