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ENZYME

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NiceZyme View of ENZYME: EC 1.14.13.41

Official Name

Tyrosine N-monooxygenase.

Alternative Name(s)

CYP79A1.

Tyrosine N-hydroxylase.

Reaction catalysed

L-tyrosine + O(2) + NADPH <=> N-hydroxy-L-tyrosine + NADP(+) + H(2)O
N-hydroxy-L-tyrosine + O(2) + NADPH <=> N,N-dihydroxy-L-tyrosine + NADP(+) + H(2)O
N,N-dihydroxy-L-tyrosine <=> (Z)-(4-hydroxyphenylacetaldehyde oxime) + CO(2) + H(2)O

Cofactor(s)

Heme-thiolate.

Comment(s)

Involved in the biosynthesis of the cyanogenic glucoside dhurrin in sorghum, along with EC 1.14.13.68 and EC 2.4.1.85.
Some 2-(4-hydroxyphenyl)-1-nitroethane is formed as a side product.

Cross-references

PROSITE

BRENDA

PUMA2

PRIAM enzyme-specific profiles

KEGG Ligand Database for Enzyme Nomenclature

IUBMB Enzyme Nomenclature