Swiss Institute of Bioinformatics

NiceZyme View of ENZYME: EC 1.14.13.39

Accepted Name
Nitric-oxide synthase.
Alternative Name(s)
Endothelium-derived relaxation factor-forming enzyme.
Endothelium-derived relaxing factor synthase.
NADPH-diaphorase.
Nitric-oxide synthetase.
NO synthase.
Reaction catalysed
L-arginine + n NADPH + n H(+) + m O(2) <=> citrulline + nitric oxide + n NADP(+)
Comment(s)
The enzyme in brain, but not that induced in lung or liver by endotoxin, requires calcium. The stoichiometry is not clear, but may involve a two-electron and a one-electron oxidation step.
Cross-references
BRENDA	1.14.13.39
EC2PDB	1.14.13.39
PRIAM enzyme-specific profiles	1.14.13.39
KEGG Ligand Database for Enzyme Nomenclature	1.14.13.39
IUBMB Enzyme Nomenclature	1.14.13.39
IntEnz	1.14.13.39
MEDLINE	Find literature relating to 1.14.13.39
MetaCyc	1.14.13.39
UniProtKB/Swiss-Prot	Q66GP9, NOS1_ARATH;   P29475, NOS1_HUMAN;   Q9Z0J4, NOS1_MOUSE;   O19132, NOS1_RABIT;   P29476, NOS1_RAT;   Q29498, NOS1_SHEEP;   Q27995, NOS2_BOVIN;   O62699, NOS2_CANFA;   Q28314, NOS2_CAPHI;   Q92037, NOS2_CARAU;   O54705, NOS2_CAVPO;   Q90703, NOS2_CHICK;   P35228, NOS2_HUMAN;   O46660, NOS2_MACMU;   P29477, NOS2_MOUSE;   Q92091, NOS2_ONCMY;   P79290, NOS2_PIG;   O19114, NOS2_RABIT;   Q06518, NOS2_RAT;   P29473, NOS3_BOVIN;   Q9TUX8, NOS3_CANFA;   P97270, NOS3_CAVPO;   P29474, NOS3_HUMAN;   P70313, NOS3_MOUSE;   Q28969, NOS3_PIG;   Q62600, NOS3_RAT;   P79209, NOS3_SHEEP;   O61608, NOS_ANOST;   Q27571, NOS_DROME;   O61309, NOS_LYMST;   Q6YPG5, NOS_ORYSJ;   Q26240, NOS_RHOPR;   Q9I9M2, NOS_SQUAC;

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