| Accepted Name |
|---|
| 3-phenylpropanoate dioxygenase.
|
| Alternative Name(s) |
|---|
| 3-phenylpropionate dioxygenase. |
| Hca dioxygenase. |
| HcaA1A2CD. |
| Reaction catalysed |
|---|
- 3-phenylpropanoic acid + NADH + O(2) <=> cis-3-(2-carboxyethyl)-3,5-cyclohexadiene-1,2-diol + NAD(+)
- Cinnamic acid + NADH + O(2) <=> cis-3-(2-carboxyethenyl)-3,5-cyclohexadiene-1,2-diol + NAD(+)
|
| Cofactor(s) |
|---|
| Iron.
|
| Comment(s) |
|---|
- This enzyme catalyzes the insertion of both atoms of molecular oxygen
into positions 2 and 3 of the phenyl ring of 3-phenylpropanoate.
- The product, 3-(cis-5,6-dihydroxycyclohexa-1,3-dien-1-yl)propanoate,
is then converted into 3-(2,3-dihydroxyphenyl)propanoate, by a
dehydrogenase, with the concomitant regeneration of NADH.
- The enzyme also acts on (2E)-3-phenylprop-2-enoate (cinnamate).
|
| Cross-references |
|---|
| PROSITE | PDOC00493 |
| BRENDA | 1.14.12.19 |
| EC2PDB | 1.14.12.19 |
| PRIAM enzyme-specific profiles | 1.14.12.19 |
| KEGG Ligand Database for Enzyme Nomenclature | 1.14.12.19 |
| IUBMB Enzyme Nomenclature | 1.14.12.19 |
| IntEnz | 1.14.12.19 |
| MEDLINE | Find literature relating to 1.14.12.19 |
| MetaCyc | 1.14.12.19 |
| UniProtKB/Swiss-Prot |
| P0ABR6, HCAE_ECO57; | A8A344, HCAE_ECOHS; | P0ABR5, HCAE_ECOLI; |
| Q7N4W0, HCAE_PHOLL; | Q31XV2, HCAE_SHIBS; | Q0T1Y1, HCAE_SHIF8; |
| Q83K39, HCAE_SHIFL; | Q3YZ15, HCAE_SHISS; | A7ZPY2, HCAF_ECO24; |
| Q8XA73, HCAF_ECO57; | A8A345, HCAF_ECOHS; | Q47140, HCAF_ECOLI; |
| Q7N4V9, HCAF_PHOLL; | Q31XV1, HCAF_SHIBS; | Q0T1Y0, HCAF_SHIF8; |
| Q83K38, HCAF_SHIFL; | Q3YZ14, HCAF_SHISS; |
|
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