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ENZYME

ENZYME entry: EC 1.14.11.53

Accepted Name
mRNA N(6)-methyladenine demethylase
Reaction catalysed
2-oxoglutarate + an N(6)-methyladenosine in mRNA + O2 <=> an adenosine in mRNA + CO2 + formaldehyde + succinate
Comment(s)
  • Catalyzes oxidative demethylation of mRNA N(6)-methyladenine.
  • The FTO enzyme from human can also demethylate N(3)-methylthymine from single stranded DNA and N(3)-methyluridine from single stranded RNA with low activity.
Cross-references
BRENDA1.14.11.53
EC2PDB1.14.11.53
ExplorEnz1.14.11.53
PRIAM enzyme-specific profiles1.14.11.53
KEGG Ligand Database for Enzyme Nomenclature1.14.11.53
IUBMB Enzyme Nomenclature1.14.11.53
IntEnz1.14.11.53
MEDLINEFind literature relating to 1.14.11.53
MetaCyc1.14.11.53
Rhea expert-curated reactions1.14.11.53
UniProtKB/Swiss-Prot
Q9ZT92, AK10B_ARATHQ9SL49, AKB9B_ARATHE1BH29, ALKB5_BOVIN
Q08BA6, ALKB5_DANREQ6P6C2, ALKB5_HUMANQ3TSG4, ALKB5_MOUSE
D3ZKD3, ALKB5_RATQ6GPB5, ALKB5_XENLAQ66JG8, ALKB5_XENTR
F1PLN3, FTO_CANLFQ9C0B1, FTO_HUMANQ8BGW1, FTO_MOUSE
Q5R7X0, FTO_PONABQ2A121, FTO_RATQ68F54, FTO_XENLA

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