Expasy logo

ENZYME

ENZYME entry: EC 1.1.1.270

Accepted Name
3beta-hydroxysteroid 3-dehydrogenase
Alternative Name(s)
3-keto-steroid reductase
3-KSR
Reaction catalysed
a 3beta-hydroxysteroid + NADP(+) <=> a 3-oxosteroid + H(+) + NADPH
Comment(s)
  • The enzyme acts on multiple 3beta-hydroxysteroids.
  • Participates in the biosynthesis of zemosterol and cholesterol, where it catalyzes the reaction in the opposite direction to that shown.
  • The mammalian enzyme is bifunctional and also catalyzes EC 1.1.1.62.
Cross-references
BRENDA1.1.1.270
EC2PDB1.1.1.270
ExplorEnz1.1.1.270
PRIAM enzyme-specific profiles1.1.1.270
KEGG Ligand Database for Enzyme Nomenclature1.1.1.270
IUBMB Enzyme Nomenclature1.1.1.270
IntEnz1.1.1.270
MEDLINEFind literature relating to 1.1.1.270
MetaCyc1.1.1.270
Rhea expert-curated reactions1.1.1.270
UniProtKB/Swiss-Prot
P14060, 3BHS1_HUMANP27365, 3BHS1_MACMUQ60555, 3BHS1_MESAU
P24815, 3BHS1_MOUSEP22071, 3BHS1_RATO35296, 3BHS3_MESAU
Q61767, 3BHS4_MOUSEQ61694, 3BHS5_MOUSEP27364, 3BHS5_RAT
P56937, DHB7_HUMANO88736, DHB7_MOUSEQ62904, DHB7_RAT
Q3ZBV9, DHR11_BOVINQ71R50, DHR11_CHICKQ6UWP2, DHR11_HUMAN
Q3U0B3, DHR11_MOUSEQ5A888, ERG27_CANALQ874K0, ERG27_CANAX
Q6FIV3, ERG27_CANGAQ6BNP0, ERG27_DEBHAQ74ZZ0, ERG27_EREGS
Q6CJC2, ERG27_KLULAO74732, ERG27_SCHPOQ6CE88, ERG27_YARLI
Q12452, ERG27_YEASTQ60A54, SDMB_METCA

View entry in original ENZYME format
View entry in raw text format (no links)
All UniProtKB/Swiss-Prot entries referenced in this entry, with possibility to download in different formats, align etc.
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 1.1.1.-
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 1.1.-.-
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 1.-.-.-