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NiceZyme View of ENZYME: EC 1.1.1.261

Accepted Name
sn-glycerol-1-phosphate dehydrogenase.
Alternative Name(s)
Glycerol-1-phosphate dehydrogenase (NAD(P)(+)).
Gro1PDH.
Reaction catalysed
sn-glycerol-1-phosphate + NAD(P)(+) <=> glycerone phosphate + NAD(P)H
Cofactor(s)
Nickel or zinc.
Comment(s)
  • Responsible for the formation of archaea-specific sn-glycerol-1- phosphate, the first step in the biosynthesis of polar lipids in archaea.
  • It is the enantiomer of sn-glycerol 3-phosphate, the form of glycerophosphate found in bacteria and eukaryotes.
  • The other enzymes involved in the biosynthesis of polar lipids in archaea are EC 2.5.1.41 and EC 2.5.1.42, which together alkylate the hydroxy groups of glycerol 1-phosphate to give unsaturated archaetidic acid, which is acted upon by EC 2.7.7.67 to form CDP- unsaturated archaeol.
  • The final step in the pathway involves the addition of L-serine, with concomitant removal of CMP, leading to the production of unsaturated archaetidylserine.
  • Activity of the enzyme is stimulated by K(+).
Cross-references
BRENDA1.1.1.261
EC2PDB1.1.1.261
PRIAM enzyme-specific profiles1.1.1.261
KEGG Ligand Database for Enzyme Nomenclature1.1.1.261
IUBMB Enzyme Nomenclature1.1.1.261
IntEnz1.1.1.261
MEDLINEFind literature relating to 1.1.1.261
MetaCyc1.1.1.261
UniProtKB/Swiss-Prot
Q9YER2, G1PDH_AERPE;  O28599, G1PDH_ARCFU;  A7Z7G4, G1PDH_BACA2;  
Q9KBR3, G1PDH_BACHD;  Q65GC3, G1PDH_BACLD;  Q5WL08, G1PDH_BACSK;  
B3EYN8, G1PDH_BACST;  P94527, G1PDH_BACSU;  A8MC03, G1PDH_CALMQ;  
A0RXV2, G1PDH_CENSY;  A4IP94, G1PDH_GEOTN;  Q5V5G2, G1PDH_HALMA;  
B0R3A6, G1PDH_HALS3;  Q9HS49, G1PDH_HALSA;  Q18JW6, G1PDH_HALWD;  
A2BN26, G1PDH_HYPBU;  A8ABP9, G1PDH_IGNH4;  B1L7K1, G1PDH_KORCO;  
A6UUD2, G1PDH_META3;  Q8TJU1, G1PDH_METAC;  A7I9R4, G1PDH_METB6;  
Q46FR7, G1PDH_METBF;  Q12X59, G1PDH_METBU;  Q2FPC7, G1PDH_METHJ;  
Q58122, G1PDH_METJA;  Q8TW08, G1PDH_METKA;  A2ST19, G1PDH_METLZ;  
A4FZY2, G1PDH_METM5;  A9A874, G1PDH_METM6;  A6VIL2, G1PDH_METM7;  
Q8PZA4, G1PDH_METMA;  A3CX71, G1PDH_METMJ;  Q6M0P4, G1PDH_METMP;  
A5UJW3, G1PDH_METS3;  A4YIZ1, G1PDH_METS5;  Q2NFL8, G1PDH_METST;  
P72010, G1PDH_METTH;  A0B5P3, G1PDH_METTP;  A6URL4, G1PDH_METVS;  
Q3ING6, G1PDH_NATPD;  A9A2U8, G1PDH_NITMS;  Q6L0R7, G1PDH_PICTO;  
Q9V0V0, G1PDH_PYRAB;  Q8ZWP5, G1PDH_PYRAE;  A4WLW1, G1PDH_PYRAR;  
A3MTM6, G1PDH_PYRCJ;  Q8U147, G1PDH_PYRFU;  O59144, G1PDH_PYRHO;  
A1RV58, G1PDH_PYRIL;  Q5JH91, G1PDH_PYRKO;  A3DN28, G1PDH_STAMF;  
Q4JB01, G1PDH_SULAC;  Q9UXE7, G1PDH_SULSO;  P58460, G1PDH_SULTO;  
Q9HJ16, G1PDH_THEAC;  B1YCY7, G1PDH_THENV;  A1RZJ9, G1PDH_THEPD;  
Q979B1, G1PDH_THEVO;  Q0W4M8, G1PDH_UNCMA;  

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