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HAMAP rule MF_00316

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General rule information [?]

Accession MF_00316
Dates 1-JUN-2001 (Created)
1-JUN-2023 (Last updated, Version 35)
Name MobA
Scope(s) Bacteria
Archaea
Template(s) P32173 (MOBA_ECOLI); [ Recover all ]
Triggered by HAMAP; MF_00316 (Get profile general information and statistics)

Propagated annotation [?]

Identifier, protein and gene names [?]

Identifier MOBA
case <OC:Pseudomonadota>
Protein name RecName: Full=Molybdenum cofactor guanylyltransferase;
                 Short=MoCo guanylyltransferase;
                 EC=2.7.7.77;
AltName: Full=GTP:molybdopterin guanylyltransferase;
AltName: Full=Molybdopterin-guanine dinucleotide synthase;
                 Short=MGD synthase;
AltName: Full=Molybdopterin guanylyltransferase;
AltName: Full=Mo-MPT guanylyltransferase;
else
Protein name RecName: Full=Probable molybdenum cofactor guanylyltransferase;
                 Short=MoCo guanylyltransferase;
                 EC=2.7.7.77;
AltName: Full=GTP:molybdopterin guanylyltransferase;
AltName: Full=Molybdopterin-guanine dinucleotide synthase;
                 Short=MGD synthase;
AltName: Full=Molybdopterin guanylyltransferase;
AltName: Full=Mo-MPT guanylyltransferase;
end case
Gene name Name=mobA;

Comments [?]

FUNCTIONTransfers a GMP moiety from GTP to Mo-molybdopterin (Mo-MPT) cofactor (Moco or molybdenum cofactor) to form Mo-molybdopterin guanine dinucleotide (Mo-MGD) cofactor.
CATALYTIC ACTIVITY Reaction=GTP + H(+) + Mo-molybdopterin = diphosphate + Mo-molybdopterin guanine dinucleotide; Xref=Rhea:RHEA:34243, ChEBI:CHEBI:15378, ChEBI:CHEBI:33019, ChEBI:CHEBI:37565, ChEBI:CHEBI:71302, ChEBI:CHEBI:71310; EC=2.7.7.77;
COFACTOR Name=Mg(2+); Xref=ChEBI:CHEBI:18420;
case <OC:Pseudomonadota>
SUBUNITMonomer.
end case
DOMAINThe N-terminal domain determines nucleotide recognition and specific binding, while the C-terminal domain determines the specific binding to the target protein.
SUBCELLULAR LOCATIONCytoplasm.
SIMILARITYBelongs to the MobA family.

Keywords [?]


Gene Ontology [?]

GO:0005525; Molecular function:GTP binding
GO:0070568; Molecular function:guanylyltransferase activity
GO:0019720; Biological process:Mo-molybdopterin cofactor metabolic process
GO:0005737; Cellular component:cytoplasm

Cross-references [?]

NCBIfam TIGR02665; Molyb_mobA; 1;

Features [?]

From: MOBA_ECOLI (P32173)
Key From To Description Tag Condition FTGroup
BINDING 12 14 /ligand="GTP"
/ligand_id="ChEBI:CHEBI:37565"
[LFIVT]-x-G
BINDING 101 101 /ligand="Mg(2+)"
/ligand_id="ChEBI:CHEBI:18420"
D
BINDING 25 25 /ligand="GTP"
/ligand_id="ChEBI:CHEBI:37565"
[KR]
BINDING 53 53 /ligand="GTP"
/ligand_id="ChEBI:CHEBI:37565"
[NRHK]
BINDING 71 71 /ligand="GTP"
/ligand_id="ChEBI:CHEBI:37565"
D
BINDING 101 101 /ligand="GTP"
/ligand_id="ChEBI:CHEBI:37565"
D

Additional information [?]

Size range 189-225 amino acids
Related rules None
Fusion Nter: MF_01224 (moaC) Cter: None



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