HAMAP rule MF_00259
General rule information
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Accession | MF_00259 |
Dates | 1-JUN-2001 (Created)
14-SEP-2023 (Last updated, Version 26) |
Name | GcvT |
Scope(s) |
Bacteria Archaea |
Template(s) | P27248 (GCST_ECOLI); [ Recover all ] |
Triggered by |
HAMAP; MF_00259 (Get profile general information and statistics) |
Propagated annotation
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Identifier, protein and gene names
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Identifier | GCST |
case <OC:Bacteria> | |
Protein name | RecName: Full=Aminomethyltransferase; EC=2.1.2.10; AltName: Full=Glycine cleavage system T protein; |
end case | |
case <OC:Archaea> | |
Protein name | RecName: Full=Probable aminomethyltransferase; EC=2.1.2.10; AltName: Full=Glycine cleavage system T protein; |
end case | |
Gene name | Name=gcvT; |
Comments
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FUNCTION | The glycine cleavage system catalyzes the degradation of glycine. |
CATALYTIC ACTIVITY | Reaction=(6S)-5,6,7,8-tetrahydrofolate + N(6)-[(R)-S(8)- aminomethyldihydrolipoyl]-L-lysyl-[protein] = (6R)-5,10-methylene- 5,6,7,8-tetrahydrofolate + N(6)-[(R)-dihydrolipoyl]-L-lysyl-[protein] + NH4(+); Xref=Rhea:RHEA:16945, Rhea:RHEA-COMP:10475, Rhea:RHEA- COMP:10492, ChEBI:CHEBI:15636, ChEBI:CHEBI:28938, ChEBI:CHEBI:57453, ChEBI:CHEBI:83100, ChEBI:CHEBI:83143; EC=2.1.2.10; |
SUBUNIT | The glycine cleavage system is composed of four proteins: P, T, L and H. |
SIMILARITY | Belongs to the GcvT family. |
Keywords
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Gene Ontology
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GO:0004047; Molecular function:aminomethyltransferase activity |
GO:0019464; Biological process:glycine decarboxylation via glycine cleavage system |
Cross-references
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Features
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Additional information
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Size range | 349-401 amino acids |
Related rules |
None |
Fusion | Nter: None Cter: None |