HAMAP rule MF_00042
General rule information
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Accession | MF_00042 |
Dates | 1-JUN-2001 (Created)
19-NOV-2022 (Last updated, Version 36) |
Name | RNase_H |
Scope(s) |
Bacteria |
Template(s) | P0A7Y4 (RNH_ECOLI); P29253 (RNH_THET8); [ Recover all ] |
Triggered by |
HAMAP; MF_00042 (Get profile general information and statistics) |
Propagated annotation
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Identifier, protein and gene names
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Identifier | RNH |
Protein name | RecName: Full=Ribonuclease H; Short=RNase H; EC=3.1.26.4; |
Gene name | Name=rnhA; |
Comments
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FUNCTION | Endonuclease that specifically degrades the RNA of RNA-DNA hybrids. |
CATALYTIC ACTIVITY | Reaction=Endonucleolytic cleavage to 5'-phosphomonoester.; EC=3.1.26.4; |
COFACTOR | Name=Mg(2+); Xref=ChEBI:CHEBI:18420; Note=Binds 1 Mg(2+) ion per subunit. May bind a second metal ion at a regulatory site, or after substrate binding.; |
SUBUNIT | Monomer. |
SUBCELLULAR LOCATION | Cytoplasm. |
SIMILARITY | Belongs to the RNase H family. |
Keywords
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Gene Ontology
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GO:0000287; Molecular function:magnesium ion binding |
GO:0004523; Molecular function:RNA-DNA hybrid ribonuclease activity |
GO:0006401; Biological process:RNA catabolic process |
GO:0005737; Cellular component:cytoplasm |
Cross-references
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Features
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From: RNH_ECOLI (P0A7Y4) | ||||||||||||
Key | From | To | Description | Tag | Condition | FTGroup | ||||||
BINDING | 10 | 10 | /ligand="Mg(2+)" /ligand_id="ChEBI:CHEBI:18420" /ligand_label="1" |
D | ||||||||
BINDING | 10 | 10 | /ligand="Mg(2+)" /ligand_id="ChEBI:CHEBI:18420" /ligand_label="2" |
D | ||||||||
BINDING | 48 | 48 | /ligand="Mg(2+)" /ligand_id="ChEBI:CHEBI:18420" /ligand_label="1" |
E | ||||||||
BINDING | 70 | 70 | /ligand="Mg(2+)" /ligand_id="ChEBI:CHEBI:18420" /ligand_label="1" |
D | ||||||||
BINDING | 134 | 134 | /ligand="Mg(2+)" /ligand_id="ChEBI:CHEBI:18420" /ligand_label="2" |
D |
Additional information
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Size range | 143-231 amino acids |
Related rules |
None |
Fusion | Nter: None Cter: None |
Comments | Possible C-terminal domain in STRCO. Divergence in TREPA. |