PROSITE documentation PDOC00970Eukaryotic initiation factor 1A signature
Description
Eukaryotic translation initiation factor 1A (eIF-1A) [1] (formerly known as eiF-4C) is a protein that seems to be required for maximal rate of protein biosynthesis. It enhances ribosome dissociation into subunits and stabilizes the binding of the initiator Met-tRNA to 40S ribosomal subunits.
eIF-1A is a hydrophilic protein of about 15 to 17 Kd. Archaebacteria also seem to possess a eIF-1A homolog.
As a signature pattern, we selected a conserved region in the central section of these proteins.
Last update:December 2004 / Pattern and text revised.
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Technical section
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Reference
| 1 | Authors | Wei C.-L. Kainuma M. Hershey J.W.B. |
| Title | Characterization of yeast translation initiation factor 1A and cloning of its essential gene. | |
| Source | J. Biol. Chem. 270:22788-22794(1995). | |
| PubMed ID | 7559407 |
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