PROSITE documentation PDOC00860
Xanthine/uracil permeases family signature

Description

The following transport proteins which are involved in the uptake of xanthine or uracil are evolutionary related [1]:

Uric uric acid-xanthine permease (gene uapA) from Aspergillus nidulans.
Purine permease (gene uapC) from Aspergillus nidulans.
Xanthine permease from Bacillus subtilis (gene pbuX).
Uracil permease from Escherichia coli (gene uraA) [2] and Bacillus (gene pyrP).
Hypothetical protein ycdG from Escherichia coli.
Hypothetical protein ygfO from Escherichia coli.
Hypothetical protein ygfU from Escherichia coli.
Hypothetical protein yicE from Escherichia coli.
Hypothetical protein yunJ from Bacillus subtilis.
Hypothetical protein yunK from Bacillus subtilis.

They are proteins of from 430 to 595 residues that seem to contain 12 transmembrane domains. As a signature pattern, we selected the best conserved region which corresponds with what seems to be the tenth transmembrane domain.

Last update:

December 2004 / Pattern and text revised.

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Technical section

PROSITE method (with tools and information) covered by this documentation:

XANTH_URACIL_PERMASE, PS01116; Xanthine/uracil permeases family signature (PATTERN)

Consensus pattern:
[LIVM]-P-x-[PASIF]-V-[LIVMG]-[GF]-[GA]-x(4)-[LIVM]-[FY]-[GSA]-x-[LIVM]-x(3)-[GA]
Sequences in UniProtKB/Swiss-Prot known to belong to this class: 55
- detected by PS01116: 29 (true positives)
- undetected by PS01116: 26 (26 false negatives and 0 'partial')
Other sequence(s) in UniProtKB/Swiss-Prot detected by PS01116:
NONE.
Retrieve an alignment of UniProtKB/Swiss-Prot true positive hits:
Clustal format, color, condensed view / Clustal format, color / Clustal format, plain text / Fasta format
Retrieve the sequence logo from the alignment
Taxonomic distribution of all UniProtKB (Swiss-Prot + TrEMBL) entries matching PS01116
Retrieve a list of all UniProtKB (Swiss-Prot + TrEMBL) entries matching PS01116
Scan UniProtKB (Swiss-Prot and/or TrEMBL) entries against PS01116
View ligand binding statistics of PS01116
Matching PDB structures: 3QE7 5I6C 5XLS [ALL]

References

1	Authors	Diallinas G. Gorfinkiel L. Arst H.N. Jr. Cecchetto G. Scazzocchio C.
	Title	Genetic and molecular characterization of a gene encoding a wide specificity purine permease of Aspergillus nidulans reveals a novel family of transporters conserved in prokaryotes and eukaryotes.
	Source	J. Biol. Chem. 270:8610-8622(1995).
	PubMed ID	7721763

2	Authors	Andersen P.S. Frees D. Fast R. Mygind B.
	Title	Uracil uptake in Escherichia coli K-12: isolation of uraA mutants and cloning of the gene.
	Source	J. Bacteriol. 177:2008-2013(1995).
	PubMed ID	7721693

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PROSITE documentation PDOC00860Xanthine/uracil permeases family signature

PROSITE documentation PDOC00860
Xanthine/uracil permeases family signature