PROSITE documentation PDOC00368Synaptobrevin signature
Synaptobrevin [1] is an intrinsic membrane protein of small synaptic vesicles whose function is not yet known, but which is highly conserved in mammals, electric ray (where its is known as VAMP-1), Drosophila and yeast [2]. In yeast there are two closely related forms of synaptobrevin (genes SNC1 and SNC2) while in mammals there is at least 4 (genes SYB1, SYB2, SYB3 and SYBL1).
Structurally synaptobrevin consist of a N-terminal cytoplasmic domain of from 90 to 110 residues, followed by a transmembrane region, and then by a short (from 2 to 22 residues) C-terminal intravesicular domain.
As a signature pattern for synaptobrevin we selected a highly conserved stretch of residues located in the central part of the sequence.
Last update:April 2006 / Pattern revised.
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PROSITE method (with tools and information) covered by this documentation:
| 1 | Authors | Suedhof T.C. Baumert M. Perin M.S. Jahn R. |
| Source | Neuron 2:1475-1481(1989). |
| 2 | Authors | Gerst J.E. Rodgers L. Riggs M. Wigler M. |
| Title | SNC1, a yeast homolog of the synaptic vesicle-associated membrane protein/synaptobrevin gene family: genetic interactions with the RAS and CAP genes. | |
| Source | Proc. Natl. Acad. Sci. U.S.A. 89:4338-4342(1992). | |
| PubMed ID | 1316605 |
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