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ENZYME

ENZYME entry: EC 2.7.1.91

Accepted Name
sphingosine kinase
Alternative Name(s)
dihydrosphingosine kinase
sphinganine kinase
sphingoid base kinase
Reaction catalysed
a sphingoid base + ATP <=> a sphingoid 1-phosphate + ADP + H(+)
Comment(s)
  • The enzyme is involved in the production of sphingolipid metabolites.
  • It phosphorylates various sphingoid long-chain bases, such as sphingosine, D-erythro-dihydrosphingosine (sphinganine), phytosphingosine (4-hydroxysphinganine), 4-hydroxy-8-sphingenine, 4,8-sphingadienine and D-threo-dihydrosphingosine and L-threo- dihydrosphingosine.
  • The exact substrate range depends on the species.
Cross-references
BRENDA2.7.1.91
EC2PDB2.7.1.91
ExplorEnz2.7.1.91
PRIAM enzyme-specific profiles2.7.1.91
KEGG Ligand Database for Enzyme Nomenclature2.7.1.91
IUBMB Enzyme Nomenclature2.7.1.91
IntEnz2.7.1.91
MEDLINEFind literature relating to 2.7.1.91
MetaCyc2.7.1.91
Rhea expert-curated reactions2.7.1.91
UniProtKB/Swiss-Prot
O14159, LCB4_SCHPOQ12246, LCB4_YEASTQ06147, LCB5_YEAST
Q8L7L1, SPHK1_ARATHQ18425, SPHK1_CAEELQ9NYA1, SPHK1_HUMAN
Q8CI15, SPHK1_MOUSEQ91V26, SPHK1_RATF2Y4A3, SPHK2_ARATH
Q9NRA0, SPHK2_HUMANQ9JIA7, SPHK2_MOUSEQ86KF9, SPHKA_DICDI
Q6B516, SPHKB_DICDI

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All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 2.7.1.-
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 2.7.-.-
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