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ENZYME

ENZYME entry: EC 2.7.1.153

Accepted Name
phosphatidylinositol-4,5-bisphosphate 3-kinase
Alternative Name(s)
type I phosphoinositide 3-kinase
Reaction catalysed
a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-4,5-bisphosphate) + ATP <=> a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-3,4,5-trisphosphate) + ADP + H(+)
Comment(s)
This enzyme also catalyzes the phosphorylation of PtdIns4P to PtdIns(3,4)P2, and of PtdIns to PtdIns3P.
Cross-references
BRENDA2.7.1.153
EC2PDB2.7.1.153
ExplorEnz2.7.1.153
PRIAM enzyme-specific profiles2.7.1.153
KEGG Ligand Database for Enzyme Nomenclature2.7.1.153
IUBMB Enzyme Nomenclature2.7.1.153
IntEnz2.7.1.153
MEDLINEFind literature relating to 2.7.1.153
MetaCyc2.7.1.153
Rhea expert-curated reactions2.7.1.153
UniProtKB/Swiss-Prot
Q8NFU5, IPMK_HUMANQ7TT16, IPMK_MOUSEQ99NI4, IPMK_RAT
O00443, P3C2A_HUMANQ61194, P3C2A_MOUSEQ5RAY1, P3C2A_PONAB
P32871, PK3CA_BOVINP42336, PK3CA_HUMANP42337, PK3CA_MOUSE
A0A0G2K344, PK3CA_RATP42338, PK3CB_HUMANQ8BTI9, PK3CB_MOUSE
Q9Z1L0, PK3CB_RATO00329, PK3CD_HUMANO35904, PK3CD_MOUSE
P48736, PK3CG_HUMANQ9JHG7, PK3CG_MOUSEO02697, PK3CG_PIG

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All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 2.7.1.-
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 2.7.-.-
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