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ENZYME

ENZYME entry: EC 2.3.2.24

Accepted Name
(E3-independent) E2 ubiquitin-conjugating enzyme
Alternative Name(s)
E3-independent ubiquitin-conjugating enzyme E2
Reaction catalysed
S-ubiquitinyl-[E1 ubiquitin-activating enzyme]-L-cysteine + [acceptor protein]-L-lysine <=> [E1 ubiquitin-activating enzyme]-L-cysteine + N(6)-monoubiquitinyl-[acceptor protein]-L-lysine
Comment(s)
  • The enzyme transfers a single ubiquitin directly from an ubiquitinated E1 ubiquitin-activating enzyme to itself, and on to a lysine residue of the acceptor protein without involvement of E3 ubiquitin transferases (cf. EC 2.3.2.26, EC 2.3.2.27).
  • It forms a labile ubiquitin adduct in the presence of E1, ubiquitin, and Mg(2+)-ATP and catalyzes the conjugation of ubiquitin to protein substrates, independently of E3.
  • This transfer has only been observed with small proteins.
  • In vitro a transfer to small acceptors (e.g. L-lysine, N-acetyl-L- lysine methyl ester) has been observed.
Cross-references
BRENDA2.3.2.24
EC2PDB2.3.2.24
ExplorEnz2.3.2.24
PRIAM enzyme-specific profiles2.3.2.24
KEGG Ligand Database for Enzyme Nomenclature2.3.2.24
IUBMB Enzyme Nomenclature2.3.2.24
IntEnz2.3.2.24
MEDLINEFind literature relating to 2.3.2.24
MetaCyc2.3.2.24
Rhea expert-curated reactions2.3.2.24
UniProtKB/Swiss-Prot
Q2TA10, UB2D1_BOVINP51668, UB2D1_HUMANP61080, UB2D1_MOUSE
D3ZDK2, UB2D1_RATQ1RMX2, UB2D2_BOVINP62837, UB2D2_HUMAN
P62838, UB2D2_MOUSEQ06AA9, UB2D2_PIGP62839, UB2D2_RAT
P62840, UB2D2_XENLAQ3ZCF7, UB2D3_BOVINP61077, UB2D3_HUMAN
Q4R5N4, UB2D3_MACFAP61079, UB2D3_MOUSEQ5R4V7, UB2D3_PONAB
P61078, UB2D3_RATP51965, UB2E1_HUMANP52482, UB2E1_MOUSE
P49427, UB2R1_HUMANQ8CFI2, UB2R1_MOUSEQ32PA5, UBE2C_BOVIN
Q9VTY6, UBE2C_DROMEO00762, UBE2C_HUMANQ4R9D1, UBE2C_MACFA
Q9D1C1, UBE2C_MOUSEQ95044, UBE2C_SPISOP56616, UBE2C_XENLA
Q32LN1, UBE2H_BOVINP62256, UBE2H_HUMANP62257, UBE2H_MOUSE
Q9C0C9, UBE2O_HUMANQ6ZPJ3, UBE2O_MOUSE

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