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ENZYME

ENZYME entry: EC 2.3.1.162

Accepted Name
taxadien-5alpha-ol O-acetyltransferase
Alternative Name(s)
taxa-4(20),11(12)-dien-5alpha-ol O-acetyltransferase
taxadienol acetyltransferase
Reaction catalysed
acetyl-CoA + taxa-4(20),11-dien-5alpha-ol <=> CoA + taxa-4(20),11-dien-5alpha-yl acetate
Comment(s)
This is the third enzyme in the biosynthesis of the diterpenoid antineoplastic drug taxol (paclitaxel), which is widely used in the treatment of carcinomas, sarcomas and melanomas.
Cross-references
BRENDA2.3.1.162
EC2PDB2.3.1.162
ExplorEnz2.3.1.162
PRIAM enzyme-specific profiles2.3.1.162
KEGG Ligand Database for Enzyme Nomenclature2.3.1.162
IUBMB Enzyme Nomenclature2.3.1.162
IntEnz2.3.1.162
MEDLINEFind literature relating to 2.3.1.162
MetaCyc2.3.1.162
Rhea expert-curated reactions2.3.1.162
UniProtKB/Swiss-Prot
Q8S9G6, T5AT_TAXCHQ9M6F0, T5AT_TAXCU

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