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ENZYME

ENZYME entry: EC 1.5.99.4

Accepted Name
nicotine 6-hydroxylase
Alternative Name(s)
D-nicotine oxidase
L-nicotine oxidase
nicotine dehydrogenase
Reaction catalysed
(S)-nicotine + A + H2O <=> (S)-6-hydroxynicotine + AH2
Comment(s)
  • A metalloprotein (FMN).
  • The enzyme can act on both the naturally found (S)-enantiomer and the synthetic (R)-enantiomer of nicotine, with retention of configuration in both cases.
Cross-references
BRENDA1.5.99.4
EC2PDB1.5.99.4
ExplorEnz1.5.99.4
PRIAM enzyme-specific profiles1.5.99.4
KEGG Ligand Database for Enzyme Nomenclature1.5.99.4
IUBMB Enzyme Nomenclature1.5.99.4
IntEnz1.5.99.4
MEDLINEFind literature relating to 1.5.99.4
MetaCyc1.5.99.4
Rhea expert-curated reactions1.5.99.4
UniProtKB/Swiss-Prot
Q93NH5, NDHL_PAENIQ59127, NDHM_PAENIQ59128, NDHS_PAENI

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