Expasy logo

ENZYME

ENZYME entry: EC 1.2.3.3

Accepted Name
pyruvate oxidase
Alternative Name(s)
phosphate-dependent pyruvate oxidase
pyruvic oxidase
Reaction catalysed
H(+) + O2 + phosphate + pyruvate <=> acetyl phosphate + CO2 + H2O2
Comment(s)
  • Two reducing equivalents are transferred from the resonant carbanion/enamine forms of 2-hydroxyethyl-thiamine-diphosphate to the adjacent flavin cofactor, yielding 2-acetyl-thiamine diphosphate (AcThDP) and reduced flavin.
  • FADH is reoxidized by O2 to yield H2O2 and FAD and AcThDP is cleaved phosphorolytically to acetyl phosphate and thiamine diphosphate.
Cross-references
BRENDA1.2.3.3
EC2PDB1.2.3.3
ExplorEnz1.2.3.3
PRIAM enzyme-specific profiles1.2.3.3
KEGG Ligand Database for Enzyme Nomenclature1.2.3.3
IUBMB Enzyme Nomenclature1.2.3.3
IntEnz1.2.3.3
MEDLINEFind literature relating to 1.2.3.3
MetaCyc1.2.3.3
Rhea expert-curated reactions1.2.3.3
UniProtKB/Swiss-Prot
P37063, POXB_LACPLQ54970, POXB_STRPN

View entry in original ENZYME format
View entry in raw text format (no links)
All UniProtKB/Swiss-Prot entries referenced in this entry, with possibility to download in different formats, align etc.
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 1.2.3.-
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 1.2.-.-
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 1.-.-.-