This database was originally developed by the Glaxo (now GSK) group at SIB.
It is no longer maintained and has not been updated since 1996.
However, the information provided by CD40Lbase continues to be valid.
A much more up-to-date database is available.
Multiple sequence alignment of several TNF family members:
1 20 40 60 80
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116- GDEDPQIAAHVVSEANS-NAASVLQWAKKGYY--TMKSNLVMLENG-KQLTVKREGLYYVYTQVTFCSNREP----SSQRPFIVGLWLKP- Mouse CD40L
116- GDQNPQIAAHVISEASS-KTTSVLQWAEKGYY--TMSNNLVTLENG-KQLTVKRQGLYYIYAQVTFCSNREA----SSQAPFIASLCLKS- Human CD40L
136- EKKEPRSVAHLTGNPH--SRSIPLEWEDTYGT--ALIS-GVKYKK--GGLVINETGLYFVYSKVYFRGQSCN------NQPLNHKVYMRNS Mouse FasL
136- ETKKPRSVAHLTGNPR--SRSIPLEWEDTYGT--ALIS-GVKYKK--GGLVINEAGLYFVYSKVYFRGQSCN------SQPLSHKVYMRNF Rat FasL
6- QNSSDKPVAHVVANH---QVEEQLEWLSQRAN--ALLANGMDLKD--NQLVVPADGLYLVYSQVLFKGQGCP-----DYVLLTHTVSRFAI Mouse TNFa
6- RTPSDKPVAHVVANP---QAEGQLQWLNRRAN--ALLANGVELRD--NQLVVPSEGLYLIYSQVLFKGQGCP----STHVLLTHTISRIAV Human TNFa
23- THGILKPAAHLVGYP---SKQNSLLWRASTDR--AFLRHGFSLSN--NSLLIPTSGLYFVYSQVVFSGESCSPRAIPTPIYLAHEVQLFSS Mouse TNFb
23- AHSTLKPAAHLIGDP---SKQNSLLWRANTDR--AFLQDGFSLSN--NSLLVPTSGIYFVYSQVVFSGKAYSPKATSSPLYLAHEVQLFSS Human TNFb
148- DLNPELPAAHLIGAW---MSGQGLSWEASQEE--AFLRSGAQFSPT-HGLALPQDGVYYLYCHVGYRGRTPPA-GRSRARSLTLRSALYRA Mouse LyTb
82- DLSPGLPAAHLIGAP---LKGQGLGWETTKEQ--AFLTSGTQFSDA-EGLALPQDGLYYLYCLVGYRGRAPPGGGDPQGRSVTLRSSLYRA Human LyTb
93- STPSKKSWAYLQVSKH--LNNTKLSWNEDG-----TIH-GLIYQD--GNLIVQFPGLYFIVCQLQFLVQ-CS----NHSVDLTLQLLIN-- Mouse CD30L
93- RAPFKKSWAYLQVAKH--LNKTKLSWNKDG-----ILH-GVRYQD--GNLVIQFPGLYFIICQLQFLVQ-CP----NNSVDLKLELLIN-- Human CD30L
50- LESLGWDVAELQLNHTGPQQDPRLYWQGGPALGRSFLH-GPELDK--GQLRIHRDGIYMVHIQVTLAICS--STTASRHHPTTLAVGICS- Human CD27L
141- TQQGSPVFAKLLAKNQASLCNTTLNWHSQDGAGSSYLSQGLRYEEDKKELVVDSPGLYYVFLELKLSPTF-TNTGHKVQGWVSLVLQAKPQ Mouse 4-1BBL
AAAAAA A'' B'B' BBBB CCCCCCCCCCCCCCC DDDDDDDD Sec. Str.
100 120 140 160
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203- ----SIGSERILLKAANTHSSSQL---------CEQQSVHLGGVFELQAGASVFVNVTEASQVIHRVGF-SSFGLLKL Mouse CD40L
203- ----PGRFERILLRAANTHSSAKP---------CGQQSIHLGGVFELQPGASVFVNVTDPSQVSHGTGF-TSFGLLKL Human CD40L
220- ----KYPEDLVLMEEKRLNYC--------TTGQIWAHSSYLGAVFNLTSADHLYVNISQLSLINFEESK-TFFGLYKL Mouse FasL
220- ----KYPGDLVLMEEKKLNYC--------TTGQIWAHSSYLGAVFNLTVADHLYVNISQLSLINFEESK-TFFGLYKL Rat FasL
85- ----SYQEKVNLLSAVKSPCPKDTPEG--AELKPWYEPIYLGGVFQLEKGDQLSAEVNLPKYLDFAESGQVYFGVIAL Mouse TNFa
86- ----SYQTKVNLLSAIKSPCQRETPEG--AEAKPWYEPIYLGGVFQLEKGDRLSAEINRPDYLLFAESGQVYFGIIAL Human TNFa
107- ----QYPFHVPLLSAQKSVYP--------GLQGPWVRSMYQGAVFLLSKGDQLSTHTDGISHLHFSPSS-VFFGAFAL Mouse TNFb
107- ----QYPFHVPLLSSQKMVYP--------GLQEPWLHSMYHGAAFQLTQGDQLSTHTDGIPHLVLSPST-VFFGAFAL Human TNFb
232- GGAYGRGSPELLLEGAETVTPVVDPI---GYGSLWYTSVGFGGLAQLRSGERVYVNISHPDMVDYRRGK-TFFGAVMVG Mouse LyTb
167- GGAYGPGTPELLLEGAETVTPVLDPARRQGYGPLWYTSVGFGGLVQLRRGERVYVNISHPDMVDFARGK-TFFGAVMVG Human LyTb
174- --------SKIKKQTLVTVCESGVQSK--NIYQNLSQFLLHYLQVNSTISVRVDNFQYVDTNTFPLDNVLSVFLYSSSD Mouse CD30L
174- --------KHIKKQALVTVCESGMQTK--HVYQNLSQFLLDYLQVNTTISVNVDTFQYIDTSTFPLENVLSIFLYSNSD Human CD30L
139- ----PASRSISLLRLSFHQG----------------CTIVSQRLTPLARGDTLCTNLTGTLLPSRNTDE-TFFGVQWVRP Human CD27L
231- ----VDDFDNLALTVELFPCSMENKLVDRS--WSQLLLLKAGHRLSVGLRAYLHGAQDAYRDWELSYPNTTSFGLFLVKPDNPWE Mouse 4-1BBL
EEEEEEEEEEE FFFFFFFFFFF GGGGGGG HHHHHHHH Sec. Str.
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